戒指(化学)
接受者
化学
催化作用
环加成
药物化学
反应条件
立体化学
组合化学
有机化学
物理
凝聚态物理
作者
Lennart K. B. Garve,Peter G. Jones,Daniel B. Werz
标识
DOI:10.1002/anie.201704619
摘要
The first ring-opening reaction of donor-acceptor cyclopropanes to give diamines is reported. For this reaction, a 1,3-bisfunctionalization was developed using cyclopropanes, triazinanes, and Sc(OTf)3 as the catalyst, followed by treatment with acid. The reaction proceeds under very mild conditions and tolerates many functional groups. Moreover, a library of various 1,3-diazepanes, which arise as intermediates of the first formal aza-[4+3]-cycloaddition reaction with donor-acceptor cyclopropanes, was synthesized.
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