免疫系统
免疫疗法
癌症免疫疗法
癌症
启动(农业)
医学
免疫
背景(考古学)
免疫学
癌症研究
生物
内科学
植物
发芽
古生物学
作者
Jorieke Weiden,Jurjen Tel,Carl G. Figdor
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2017-08-30
卷期号:18 (3): 212-219
被引量:140
摘要
Carl Figdor and colleagues propose that delivering cancer immunotherapy in the context of engineered three-dimensional scaffolds may boost anticancer immunity. The synthetic scaffolds, which can be linked to immunomodulatory factors, can act as immune niches to support the priming and maintenance of antitumour immune responses. Cancer immunotherapy can successfully promote long-term anticancer immune responses, although there is still only a limited number of patients who benefit from such treatment, and it can sometimes have severe treatment-associated adverse events. Compared with systemic immunomodulation, local immunomodulation may enable more effective treatment at lower doses and, at the same time, prevent systemic toxicity. Local delivery of engineered three-dimensional scaffolds may fulfil this role by acting as synthetic immune niches that boost anticancer immunity. In this Opinion article, we highlight the potential of scaffold-based adoptive cell transfer and scaffold-based cancer vaccines that, although applied locally, can promote systemic antitumour immunity. Furthermore, we discuss how scaffold-based cancer immunotherapy may contribute to the development of the next generation of cancer treatments.
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