肿瘤微环境
癌症
T细胞
癌症研究
癌细胞
细胞
生物
免疫
免疫疗法
免疫学
生物信息学
免疫系统
医学
肿瘤细胞
遗传学
内科学
作者
Daniela S. Thommen,Ton N. Schumacher
出处
期刊:Cancer Cell
[Elsevier]
日期:2018-04-01
卷期号:33 (4): 547-562
被引量:782
标识
DOI:10.1016/j.ccell.2018.03.012
摘要
Therapeutic reinvigoration of tumor-specific T cells has greatly improved clinical outcome in cancer. Nevertheless, many patients still do not achieve durable benefit. Recent evidence from studies in murine and human cancer suggest that intratumoral T cells display a broad spectrum of (dys-)functional states, shaped by the multifaceted suppressive signals that occur within the tumor microenvironment. Here we discuss the current understanding of T cell dysfunction in cancer, the value of novel technologies to dissect such dysfunction at the single cell level, and how our emerging understanding of T cell dysfunction may be utilized to develop personalized strategies to restore antitumor immunity. Therapeutic reinvigoration of tumor-specific T cells has greatly improved clinical outcome in cancer. Nevertheless, many patients still do not achieve durable benefit. Recent evidence from studies in murine and human cancer suggest that intratumoral T cells display a broad spectrum of (dys-)functional states, shaped by the multifaceted suppressive signals that occur within the tumor microenvironment. Here we discuss the current understanding of T cell dysfunction in cancer, the value of novel technologies to dissect such dysfunction at the single cell level, and how our emerging understanding of T cell dysfunction may be utilized to develop personalized strategies to restore antitumor immunity.
科研通智能强力驱动
Strongly Powered by AbleSci AI