化学
二茂铁
苯并咪唑
赫拉
循环伏安法
电化学
组合化学
配体(生物化学)
立体化学
氧化还原
药物化学
有机化学
体外
受体
电极
生物化学
物理化学
作者
Sara Realista,Susana Quintal,Paulo N. Martinho,A.I. Melato,Adrià Gil,Teresa Esteves,Maria Graça Carvalho,Liliana P. Ferreira,Pedro D. Vaz,Maria José Calhorda
标识
DOI:10.1080/00958972.2016.1257125
摘要
Several ferrocene derivatives (five mononuclear and two binuclear), including the new N-(p-chlorophenyl)-carboxamidoferrocene (1), were synthesized and their anticancer activity investigated. Two of them, 3 and 7, bearing a benzimidazole backbone were the most active against HeLa cells achieving IC50 values of ~5 μM along with 4 with a dipyridylamine ligand (~6 μM). Complex 6, also with a benzimidazole backbone, displayed slightly higher values (~11 μM). Cyclic voltammetry studies show that while the non-cytotoxic ferrocene derivatives 1, 2, and 5 follow a ferrocene-based redox behavior, derivatives 3, 4, 6, and 7 exhibit a more complex mechanism. These complex mechanisms are consistent with a more effective cytotoxic activity. Mössbauer spectroscopy parameters reflect a very small influence of the substituents.
科研通智能强力驱动
Strongly Powered by AbleSci AI