氧化磷酸化
线粒体DNA
基因
微阵列
生物
氧化应激
阿尔茨海默病
微阵列分析技术
核基因
认知功能衰退
基因表达
疾病
内科学
痴呆
医学
遗传学
内分泌学
生物化学
作者
Diego Mastroeni,Omar M. Khdour,Elaine Delvaux,Jennifer Nolz,Gary J. Olsen,Nicole C. Berchtold,Carl W. Cotman,Sidney M. Hecht,Paul D. Coleman
标识
DOI:10.1016/j.jalz.2016.09.003
摘要
Abstract Introduction We have comprehensively described the expression profiles of mitochondrial DNA and nuclear DNA genes that encode subunits of the respiratory oxidative phosphorylation (OXPHOS) complexes (I–V) in the hippocampus from young controls, age matched, mild cognitively impaired (MCI), and Alzheimer's disease (AD) subjects. Methods Hippocampal tissues from 44 non‐AD controls (NC), 10 amnestic MCI, and 18 AD cases were analyzed on Affymetrix Hg‐U133 plus 2.0 arrays. Results The microarray data revealed significant down regulation in OXPHOS genes in AD, particularly those encoded in the nucleus. In contrast, there was up regulation of the same gene(s) in MCI subjects compared to AD and ND cases. No significant differences were observed in mtDNA genes identified in the array between AD, ND, and MCI subjects except one mt‐ND6 . Discussion Our findings suggest that restoration of the expression of nuclear‐encoded OXPHOS genes in aging could be a viable strategy for blunting AD progression.
科研通智能强力驱动
Strongly Powered by AbleSci AI