丝绸
纳米纤维
无定形固体
材料科学
纳米技术
自愈水凝胶
组织工程
制作
化学工程
水溶液
高分子科学
高分子化学
复合材料
化学
有机化学
生物医学工程
工程类
病理
医学
替代医学
作者
Xiaodan Dong,Qun Zhao,Liying Xiao,Qiang Lü,David L. Kaplan
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2016-08-08
卷期号:17 (9): 3000-3006
被引量:61
标识
DOI:10.1021/acs.biomac.6b00863
摘要
As a functional material, silk has been widely used in tissue engineering, drug release, and tissue regeneration. Increasing subtle control of silk hierarchical structures and thus specific functional performance is required for these applications but remains a challenge. Here, we report a novel silk nanofiber solution achieved through tuning solvent systems used to generate the material. Unlike the β-sheet rich silk nanofibers reported previously, these new silk nanofibers are mainly composed of amorphous structures and maintain a solution state in aqueous environments. The amorphous silk nanofibers are stable enough for storage and also metastable, making them easy to use in the further fabrication of materials through various processes. Silk scaffolds, hydrogels, and films were prepared from these silk nanofiber solutions. These silk materials from amorphous nanofiber solutions show different properties and tunable performance features. Therefore, these amorphous silk nanofibers are suitable units or building blocks for designing silk-based materials.
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