活性成分
固定剂量组合
风险分析(工程)
医学
生化工程
药品
活性化合物
计算机科学
药理学
业务
工程类
组合化学
化学
出处
期刊:Research Journal of Pharmaceutical Dosage Forms and Technology
[Diva Enterprises Private Limited]
日期:2016-01-01
标识
DOI:10.5958/0975-4377.2016.00028.8
摘要
A fixed dose combination (FDC) is a formulation of two or more active ingredients combined in a single dosage form available in certain fixed doses. Combination therapy with two or more agents having complementary mechanisms of action represents a type of incremental innovation that has extended the range of therapeutic options in the treatment of almost every human disease. Combining two or more active pharmaceutical ingredients in a single-dosage form can increase a drug's efficacy and improve patient compliance. Several difficulties arise during formulation development, manufacturing and regulations of FDC products. Two or more active ingredients in the FDCs must be physically and chemically compatible along with their excipients. In this review article authors provided the brief information regarding advantages, formulation development and regulations of FDC products.
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