功能磁共振成像
中央前回
辅助电机区
壳核
磁共振成像
静息状态功能磁共振成像
医学
神经科学
小脑
帕金森病
荟萃分析
听力学
心理学
大脑定位
体素
疾病
放射科
内科学
作者
PingLei Pan,Hui Zhan,Mingxu Xia,Yang Zhang,Di Guan,Yun Xu
标识
DOI:10.1016/j.neubiorev.2016.11.018
摘要
Studies of abnormal regional homogeneity (ReHo) in Parkinson’s disease (PD) have reported inconsistent results. Therefore, we conducted a meta-analysis using the Seed-based d Mapping software package to identify the most consistent and replicable findings. A systematic literature search was performed to identify eligible whole-brain resting-state functional magnetic resonance imaging studies that had measured differences in ReHo between patients with PD and healthy controls between January 2000 and June 4, 2016. A total of ten studies reporting 11 comparisons (212 patients; 182 controls) were included. Increased ReHo was consistently identified in the bilateral inferior parietal lobules, bilateral medial prefrontal cortices, and left cerebellum of patients with PD when compared to healthy controls, while decreased ReHo was observed in the right putamen, right precentral gyrus, and left lingual gyrus. The results of the current meta-analysis demonstrate a consistent and coexistent pattern of impairment and compensation of intrinsic brain activity that predominantly involves the default mode and motor networks, which may advance our understanding of the pathophysiological mechanisms underlying PD.
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