钙
贻贝
成骨细胞
磷酸盐
水解物
体内
肽
生物化学
材料科学
生物物理学
体外
化学
生物
水解
冶金
生物技术
生态学
作者
Zhe Xu,Zhixuan Zhu,Hui Chen,Lingyu Han,Peipei Shi,Xiufang Dong,Di Wu,Ming Du,Tingting Li
出处
期刊:Biomaterials
[Elsevier]
日期:2022-03-01
卷期号:282: 121390-121390
被引量:15
标识
DOI:10.1016/j.biomaterials.2022.121390
摘要
The IEELEEELEAER peptide (PIE) identified from the protein hydrolysate of Mytilus edulis is reported to enhance osteoblast growth and differentiation, which also possesses a superior bone formation ability both in vitro and in vivo. Moreover, PIE bound to calcium spontaneously at the stoichiometry of 1:1, and there were amino nitrogen and carboxyl oxygen atoms in 2 glutamic acid residues at the calcium-binding sites in the PIE. The PIE-calcium complex facilitated calcium uptake through the Caco-2 cell monolayers. Incorporation of PIE into calcium phosphate cements enhanced calcium ion uptake and proliferation of osteoblasts and inhibit bacteria. This study suggest that calcium phosphate cements supplemented with PIE can serve as a potentially efficient material for bone graft used during spinal surgery.
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