根茎
化学
细胞毒性
立体化学
过氧化氢
圆二色性
一氧化氮
HL60型
体外
传统医学
生物化学
有机化学
医学
作者
Yahui Li,Hui Wang,Hong Wang,Yingchun Wu,Yiming Li,Fujiang Guo
出处
期刊:Fitoterapia
[Elsevier]
日期:2022-04-01
卷期号:158: 105167-105167
被引量:4
标识
DOI:10.1016/j.fitote.2022.105167
摘要
Nine new sesquiterpenes wenyujinones A-I (1-9), along with ten known ones (10-19), were isolated from the rhizomes of Curcuma wenyujin Y. H. Chen et C. Ling (C. wenyujin). The chemical structures of compounds 1-9 were elucidated by NMR spectroscopic and mass spectrometric data, electronic circular dichroism (ECD) spectra analysis. Furthermore, all compounds were evaluated for the protective effects against hydrogen peroxide (H2O2)-induced injury in human hepatic L02 cells, for the inhibitory effects on nitric oxide (NO) production in RAW 264.7 cells, and for their cytotoxicity against three human cancer cell lines A549, HL60, and MCF7 in vitro. As a result, compounds 2, 4, 14 markedly weakened the oxidative damage induced by H2O2 in L02 cells via strengthening the cell viability.
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