One-Pot Synthesis of Novel 3,5-Disubstituted-1,2,4-oxadiazoles from Indazole Carboxylic Acid Esters and Amidoximes

An efficient and high-yielding one-pot synthesis of 3,5-disubstituted-1,2,4-oxadiazoles from indazole carboxylic acid methyl esters and amidoximes is described.In this study a series of novel 3,5-disubstituted-1,2,4-oxadiazoles (3a-d), (4a-d), (5a-d), (6a-d), (7a-d) were synthesized using amidoximes 2a-d and indazole carboxylic acid esters (3-6).