柠檬苦素
化学
药理学
体内
自愈水凝胶
细胞凋亡
腺癌
生物相容性
癌症研究
医学
生物化学
癌症
内科学
生物
高分子化学
有机化学
生物技术
作者
Limin Chang,Ruixue Chang,Jiafu Shen,Yong Wang,Hongzan Song,Xianjiang Kang,Youliang Zhao,Shuai Guo,Jianglei Qin
标识
DOI:10.1016/j.ijbiomac.2022.08.037
摘要
Lung cancer as one of the highest incident malignant tumors did not receive satisfactory chemotherapy due to lack of specific drug targets and targeted drugs. This study screened a new effective lung tumor inhibitor limonin from herbal medicine, which inhibited proliferation and promoted apoptosis of lung adenocarcinoma cells by targeting specific high expressed TMEM16A ion channel. Moreover, a novel biodegradable self-healing hydrogel was prepared from acylhydrazide functionalized carboxymethyl cellulose (CMC-AH) and oxidized pectin (pec-CHO) to reduce the side effects of the limonin to the body. The hydrogels showed fast gelation, good biocompatibility and sustained limonin release property. The limonin-loaded hydrogel significantly inhibited the growth of lung adenocarcinoma in xenografts mice because the limonin inhibited the proliferation, migration and promoted apoptosis of LA795 cells, and eliminated the acute toxicity through sustained release from the hydrogel. Combined the antitumor performance of the limonin and sustained release of pec-CHO/CMC-AH hydrogel, this limonin/hydrogel system achieved satisfactory antitumor effect and eliminated side effects in vivo. Therefore, this system has great potential application for enhanced lung adenocarcinoma therapy.
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