An iron-catalysed radical cyclization/C(sp3)–H alkylation cascade between γ,δ-unsaturated oxime esters and glycine derivatives: access to pyrroline-containing amino acids

An iron-catalysed and ligand-controlled selective α-C–H alkylation of N -aryl glycinates is established with γ,δ-unsaturated oxime esters as the reagent. This method provides a facile synthetic approach to obtain pyrroline-containing amino acids.