最低杀菌浓度
最小抑制浓度
铜绿假单胞菌
金黄色葡萄球菌
抗菌活性
微生物学
大肠杆菌
化学
细菌
细菌生长
琼脂扩散试验
肺炎克雷伯菌
抗菌剂
琼脂
假单胞菌
生物
生物化学
基因
遗传学
作者
Emad M. Abdallah,A. Modwi,Samiah H. Al-Mijalli,Afrah E. Mohammed,Hajo Idriss,Abdulkader Shaikh Omar,Mohamed Afifi,Haytham A. Ali,Khang Wen Goh,Long Chiau Ming
出处
期刊:Molecules
[MDPI AG]
日期:2022-11-28
卷期号:27 (23): 8309-8309
标识
DOI:10.3390/molecules27238309
摘要
In this work, ZnO, CrZnO, RuZnO, and BaZnO nanomaterials were synthesized and characterized in order to study their antibacterial activity. The agar well diffusion, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) assays were used to determine the antibacterial activity of the fabricated nanomaterials against Staphylococcus aureus ATCC 29213, Escherichia coli ATCC35218, Klebsiella pneumoniae ATCC 7000603, and Pseudomonas aeruginosa ATCC 278533. The well-diffusion test revealed significant antibacterial activity against all investigated bacteria when compared to vancomycin at a concentration of 1 mg/mL. The most susceptible bacteria to BaZnO, RuZnO, and CrZnO were Staphylococcus aureus (15.5 ± 0.5 mm), Pseudomonas aeruginosa (19.2 ± 0.5 mm), and Pseudomonas aeruginosa (19.7 ± 0.5), respectively. The MIC values indicated that they were in the range of 0.02 to 0.2 mg/mL. The MBC values showed that the tested bacteria's growth could be inhibited at concentrations ranging from 0.2 to 2.0 mg/mL. According to the MBC/MIC ratio, BaZnO, RuZnO, and CrZnO exhibit bacteriostatic effects and may target bacterial protein synthesis based on the results of the tolerance test. This study shows the efficacy of the above-mentioned nanoparticles on bacterial growth. Further biotechnological and toxicological studies on the nanoparticles fabricated here are recommended to benefit from these findings.
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