Near‐infrared Light‐accelerated Glucose Oxidase‐MoS2 Cascade Catalytic Chemodynamic Therapy in Synergistic Cationic Polymer Hydrogels to Combate Multibacterial Infection

Abstract Given the poor antibacterial activity of hydrogels, a multimodal synergistic antibacterial hydrogel based on dopamine‐modified oxidized hyaluronic acid was developed, and its antibacterial activity and biocompatibility were demonstrated. First, dopamine‐modified oxidized hyaluronic acid (OHA‐DA) was used as the hydrogel backbone. A dual‐dynamically cross‐linked injectable hydrogel was constructed by mixing OHA‐DA, Fe 3+ with cationic antimicrobial peptide polylysine (EPL) via Schiff base and coordination complexation. Next, glucose oxidase‐loaded MoS 2 nanosheets were synthesized through electrostatic interaction and loaded into the hydrogel through physical mixing. Finally, a multimodal synergistic antibacterial hydrogel OD/EPL/GM was obtained. Antibacterial experiments show that the hydrogel has good antibacterial activity against E. coli and S. aureus , and the antibacterial rate can reach 99.99%.