微泡
成核
乳状液
材料科学
纳米技术
细胞外小泡
化学工程
纳米颗粒
化学
生物物理学
细胞生物学
生物化学
有机化学
生物
小RNA
工程类
基因
作者
Lu Dong,Minchao Liu,Mingming Fang,Qianqian Lu,Xingjin Li,Yanming Ma,Tiancong Zhao
出处
期刊:Small
[Wiley]
日期:2024-04-09
标识
DOI:10.1002/smll.202400714
摘要
Albeit microemulsion systems have emerged as efficient platforms for fabricating tunable nano/microstructures, lack of understanding on the emulsion-interfacial assembly hindered the control of fabrication. Herein, a nucleation-inhibited microemulsion interfacial assembly method is proposed, which deviates from conventional interfacial nucleation approaches, for the synthesis of polydopamine microvesicles (PDA MVs). These PDA MVs exhibit an approximate diameter of 1 µm, showcasing a pliable structure reminiscent of cellular morphology. Through modifications of antibodies on the surface of PDA MVs, their capacity as artificial antigen presentation cells is evaluated. In comparison to solid nanoparticles, PDA MVs with cell-like structures show enhanced T-cell activation, resulting in a 1.5-fold increase in CD25 expression after 1 day and a threefold surge in PD-1 positivity after 7 days. In summary, the research elucidates the influence of nucleation and interfacial assembly in microemulsion polymerization systems, providing a direct synthesis method for MVs and substantiating their effectiveness as artificial antigen-presenting cells.
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