Facial Skin Aging: Effect of Aging in Different Layers of the Skin on Wrinkles and Sagging

ABSTRACT Objective To investigate the impact of aging in different skin layers on the formation of wrinkles and sagging. Methods In a single‐center clinical study, the skin micromorphology, wrinkles, and sagging of 34 participants aged 42–60 years who use an antiaging product for 56 days are discussed retrospectively and observationally. The variation trend of each parameter and the correlation between micromorphology parameters and wrinkles and sagging are analyzed. Results Parameters related to epidermal aging show a strong correlation with wrinkles and sagging, whereas parameters related to dermal aging show no significant correlation with wrinkles and sagging; in addition, parameters related to the dermal–epidermal junction (DEJ) show a moderate correlation with wrinkles and sagging. Conclusion For individuals in the rapid and stable aging phases, aging of the epidermis has a greater impact on wrinkles and sagging than aging of the dermis and DEJ.