Prenatal Exposure to Ambient Air Pollution and Fetal Growth Trajectories in Wuhan, China

BACKGROUND: While numerous studies have examined associations between prenatal air pollution exposure and fetal growth measures, investigations assessing longitudinal growth trajectories across multiple time points during mid-to-late pregnancy remain limited. OBJECTIVES: The aim of this study is to explore the effects of prenatal exposure to air pollution during pregnancy on fetal growth trajectories. METHODS: From a prospective birth cohort in Wuhan, China recruited from 2013 to 2016, we included a total of 4283 eligible pregnant women. At 16, 24, 31, and 38 weeks of gestation, we collected ultrasound measurements, including biparietal diameter (BPD), abdominal circumference (AC), femur length (FL), and estimated fetal weight (EFW). Exposure to air pollution during pregnancy was estimated for the participants' residential addresses using a spatial interpolation method. Associations between air pollutants and fetal growth parameters across four exposure windows were examined using multiple informant models. A group-based trajectory modelling (GBTM) combined with multinomial logistic regression model were used to explore the effect of air pollution exposure on fetal growth trajectories. RESULTS: , and CO during 1-16 weeks were negatively associated with AC, FL, and EFW at 16 weeks, as well as BPD, FL, and EFW at 24 weeks. While similar negative associations were observed between air pollution exposure during 25-38 weeks and AC and EFW at 38 weeks. DISCUSSION: Our study provided evidence of negative associations between air pollution exposure during 1-16 weeks gestation and fast growth trajectory group. In addition, we observed distinct lagged associations between air pollution and fetal growth, with early-pregnancy exposure negatively related to early and mid-gestational growth, and mid-to-late pregnancy exposure negatively related to growth in the late window. These results underscore the importance of identifying critical windows of susceptibility during pregnancy and support early intervention strategies to mitigate adverse fetal developmental outcomes. https://doi.org/10.1289/EHP15204.