Nano-Silica Particle Exposure Affects Pollen-Sensitized Mice via Nicotinamide Metabolism

Pollen-sensitized mice exposed to nano-SiO₂ particles can aggravate allergic reactions and induce dysregulation of the metabolism characterized by niacin and nicotinamide. Nicotinamide could stabilize mast cells and may serve as a potential therapeutic strategy for allergic diseases. Further, in-depth investigations are needed.