Rhabdomyolysis

Muscle injury resulting in markedly elevated creatine kinase levels is termed rhabdomyolysis. The muscle damage can occur because of direct or indirect trauma, or it can be related to the use of certain medications, toxins, illicit drugs, or the presence of underlying inflammatory, metabolic, or genetic disorders with a predisposition for rhabdomyolysis. A detailed review of history can help in identifying the underlying etiology. Identification and removal of the triggering/inciting factor and noxious stimuli should be attempted as soon as possible. Careful evaluation for any complications and initiation of appropriate treatment are recommended. Aggressive fluid therapy, correction of metabolic derangement, and, when warranted, renal replacement therapy, form the mainstays of treatment.