嗅球
生物
星形胶质细胞
神经科学
组蛋白
神经递质
细胞生物学
生物化学
基因
中枢神经系统
作者
Debosmita Sardar,Yi-Ting Cheng,Junsung Woo,Dong‐Joo Choi,Zhung-Fu Lee,Wookbong Kwon,Hsiao‐Chi Chen,Brittney Lozzi,Alexis Cervantes,Kavitha Rajendran,Teng-Wei Huang,Antrix Jain,Benjamin R. Arenkiel,Ian Maze,Benjamin Deneen
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2023-06-16
卷期号:380 (6650)
被引量:9
标识
DOI:10.1126/science.ade0027
摘要
Neuronal activity drives alterations in gene expression within neurons, yet how it directs transcriptional and epigenomic changes in neighboring astrocytes in functioning circuits is unknown. We found that neuronal activity induces widespread transcriptional up-regulation and down-regulation in astrocytes, highlighted by the identification of Slc22a3 as an activity-inducible astrocyte gene that encodes neuromodulator transporter Slc22a3 and regulates sensory processing in the mouse olfactory bulb. Loss of astrocytic Slc22a3 reduced serotonin levels in astrocytes, leading to alterations in histone serotonylation. Inhibition of histone serotonylation in astrocytes reduced the expression of γ-aminobutyric acid (GABA) biosynthetic genes and GABA release, culminating in olfactory deficits. Our study reveals that neuronal activity orchestrates transcriptional and epigenomic responses in astrocytes while illustrating new mechanisms for how astrocytes process neuromodulatory input to gate neurotransmitter release for sensory processing.
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