前列腺癌
KEAP1型
癌症
氧化应激
癌变
癌症研究
医学
癌细胞
肿瘤进展
前列腺
活性氧
转移
内科学
肿瘤科
生物
转录因子
细胞生物学
生物化学
基因
作者
Giovanni Tossetta,Sonia Fantone,Daniela Marzioni,Roberta Mazzucchelli
出处
期刊:Cancers
[MDPI AG]
日期:2023-06-02
卷期号:15 (11): 3037-3037
被引量:4
标识
DOI:10.3390/cancers15113037
摘要
Prostate cancer is the second most common cancer in men worldwide. Prostate cancer can be treated by surgery or active surveillance when early diagnosed but, when diagnosed at an advanced or metastatic stage, radiation therapy or androgen-deprivation therapy is needed to reduce cancer progression. However, both of these therapies can cause prostate cancer resistance to treatment. Several studies demonstrated that oxidative stress is involved in cancer occurrence, development, progression and treatment resistance. The nuclear factor erythroid 2-related factor 2 (NRF2)/KEAP1 (Kelch-Like ECH-Associated Protein 1) pathway plays an important role in protecting cells against oxidative damage. Reactive oxygen species (ROS) levels and NRF2 activation can determine cell fate. In particular, toxic levels of ROS lead physiological cell death and cell tumor suppression, while lower ROS levels are associated with carcinogenesis and cancer progression. On the contrary, a high level of NRF2 promotes cell survival related to cancer progression activating an adaptive antioxidant response. In this review, we analyzed the current literature regarding the role of natural and synthetic compounds in modulating NRF2/KEAP1 signaling pathway in prostate cancer.
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