间充质干细胞
缺氧(环境)
细胞生物学
干细胞
氧气张力
生物
衰老
表观遗传学
细胞分化
化学
生物化学
氧气
基因
有机化学
作者
Göknur Topaloğlu Yasan,Ayşen Günel-Özcan
出处
期刊:Current stem cell research & therapy
[Bentham Science]
日期:2024-01-01
卷期号:19 (1): 33-54
被引量:1
标识
DOI:10.2174/1574888x18666230113143234
摘要
Abstract: Mesenchymal stem cells (MSC) exhibit self-renewal capacity and multilineage differentiation potential, making them attractive for research and clinical application. The properties of MSC can vary depending on specific micro-environmental factors. MSC resides in specific niches with low oxygen concentrations, where oxygen functions as a metabolic substrate and a signaling molecule. Conventional physical incubators or chemically hypoxia mimetic agents are applied in cultures to mimic the original low oxygen tension settings where MSC originated. : This review aims to focus on the current knowledge of the effects of various physical hypoxic conditions and widely used hypoxia-mimetic agents-PHD inhibitors on mesenchymal stem cells at a cellular and molecular level, including proliferation, stemness, differentiation, viability, apoptosis, senescence, migration, immunomodulation behaviors, as well as epigenetic changes.
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