化学
异氰
部分
串联
组合化学
模块化设计
药物化学
有机化学
材料科学
计算机科学
复合材料
操作系统
作者
Ruyu Xie,Rui Li,Qilong Zhao,Yongxing Zhao,Jinzhong Yao,Maozhong Miao
标识
DOI:10.1021/acs.joc.2c02805
摘要
The metal-free cyclization of allenyl ketones and p-toluenesulfonylmethyl isocyanide (TosMIC), promoted by Cs2CO3, provides a convenient access to tetrasubstituted pyrroles in which an acyl group undergoes 1,2-migration. This tandem Michael addition/annulative migration synthetic strategy is general and high-yielding for various substituted allenyl ketones. Moreover, a phosphoryl or ester moiety is also a suitable functionality to enable such migration.
科研通智能强力驱动
Strongly Powered by AbleSci AI