对映体
绝对构型
立体化学
化学
一氧化氮
有机化学
作者
Mei Fang,J. Nie,Wen Yan,Zhenwei Li,Daidi Zhang,Li‐She Gan,Wei Li,De‐An Guo
标识
DOI:10.1016/j.phytochem.2023.113780
摘要
Six previously undescribed N-acetyldopamine (NADA) trimmer racemates, percicamides A-F (1-6), were isolated from a 70% ethanol extract of Cicadae Periostracum. Subsequent chiral-phase separation afforded six pairs of enantiomers, (+)- and (-)-percicamides A-F (1a/1b-6a/6b). Their structures including absolute configurations were elucidated by combined extensive spectroscopic data and quantum chemical calculations. Compounds 1-6 represent the first examples of NADA trimmers with a cis-relationship of H-7'/H-8' or H-7''/H-8''. Bioassays verified that all isolated compounds showed weak inhibitory effects on nitric oxide production in RAW 264.7 cells.
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