神经科学
纹状体
神经调节
脑深部刺激
心理学
运动学习
磁刺激
神经影像学
功能磁共振成像
刺激
医学
多巴胺
帕金森病
疾病
病理
作者
Maximilian J. Wessel,Elena Beanato,Traian Popa,Fabienne Windel,Pierre Vassiliadis,Pauline Menoud,Valeriia Beliaeva,Inês R. Violante,Hedjoudje Abderrahmane,Patrycja Dzialecka,Chang-Hyun Park,Pablo Maceira-Elvira,Takuya Morishita,Antonino M. Cassará,Melanie Steiner,Nir Grossman,Esra Neufeld,Friedhelm C. Hummel
标识
DOI:10.1038/s41593-023-01457-7
摘要
The stimulation of deep brain structures has thus far only been possible with invasive methods. Transcranial electrical temporal interference stimulation (tTIS) is a novel, noninvasive technology that might overcome this limitation. The initial proof-of-concept was obtained through modeling, physics experiments and rodent models. Here we show successful noninvasive neuromodulation of the striatum via tTIS in humans using computational modeling, functional magnetic resonance imaging studies and behavioral evaluations. Theta-burst patterned striatal tTIS increased activity in the striatum and associated motor network. Furthermore, striatal tTIS enhanced motor performance, especially in healthy older participants as they have lower natural learning skills than younger subjects. These findings place tTIS as an exciting new method to target deep brain structures in humans noninvasively, thus enhancing our understanding of their functional role. Moreover, our results lay the groundwork for innovative, noninvasive treatment strategies for brain disorders in which deep striatal structures play key pathophysiological roles.
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