A universe of second messengers for cGLR-STING signaling

2′3′-cyclic GMP-AMP (2′3′-cGAMP) and 3′2′-cGAMP activate STING-dependent antiviral immunity in Drosophila melanogaster but fail to control infection by C virus in some fly species. In this issue of Immunity, Cai et al. reveal that Drosophila produces multiple cyclic di-nucleotides (CDNs) in response to viral infection. One of these CDNs—2′3′-c-di-GMP—is a very potent STING activator capable of promoting antiviral immunity in otherwise susceptible flies. 2′3′-cyclic GMP-AMP (2′3′-cGAMP) and 3′2′-cGAMP activate STING-dependent antiviral immunity in Drosophila melanogaster but fail to control infection by C virus in some fly species. In this issue of Immunity, Cai et al. reveal that Drosophila produces multiple cyclic di-nucleotides (CDNs) in response to viral infection. One of these CDNs—2′3′-c-di-GMP—is a very potent STING activator capable of promoting antiviral immunity in otherwise susceptible flies. The virus-induced cyclic dinucleotide 2′3′-c-di-GMP mediates STING-dependent antiviral immunity in DrosophilaCai et al.ImmunitySeptember 1, 2023In BriefIn the model organism Drosophila melanogaster, two cGAS-like receptors participate in antiviral host-defense. Cai et al. explore STING-dependent immunity in several Drosophila species and report that flies encode up to seven cGAS-like receptors, which can produce distinct cyclic dinucleotide signals in response to viral infection. Full-Text PDF