Venous Thromboembolism Polygenic Risk Score Associates With Pulmonary Hypertension in the UK Biobank

HomeCirculation: Genomic and Precision MedicineVol. 15, No. 6Venous Thromboembolism Polygenic Risk Score Associates With Pulmonary Hypertension in the UK Biobank No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextVenous Thromboembolism Polygenic Risk Score Associates With Pulmonary Hypertension in the UK Biobank Katharine R. Clapham, MD, Md Mesbah Uddin, PhD, Michael C. Honigberg, MD, MPP, Thomas Gilliland, MD, Yunfeng Ruan, PhD and Pradeep Natarajan, MD, MMSc Katharine R. ClaphamKatharine R. Clapham https://orcid.org/0000-0003-3659-4755 Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital (K.R.C.). Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard, Cambridge (K.R.C., M.M.U., M.C.H., T.G., Y.R., P.N.). Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA (K.R.C., M.M.U., M.C.H., T.G., P.N.). Search for more papers by this author , Md Mesbah UddinMd Mesbah Uddin https://orcid.org/0000-0003-1846-0411 Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard, Cambridge (K.R.C., M.M.U., M.C.H., T.G., Y.R., P.N.). Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA (K.R.C., M.M.U., M.C.H., T.G., P.N.). Search for more papers by this author , Michael C. HonigbergMichael C. Honigberg https://orcid.org/0000-0001-8630-5021 Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard, Cambridge (K.R.C., M.M.U., M.C.H., T.G., Y.R., P.N.). Cardiology Division, Massachusetts General Hospital (M.C.H., T.G., P.N.). Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (M.C.H., T.G., P.N.). Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA (K.R.C., M.M.U., M.C.H., T.G., P.N.). Search for more papers by this author , Thomas GillilandThomas Gilliland https://orcid.org/0000-0002-2872-9608 Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard, Cambridge (K.R.C., M.M.U., M.C.H., T.G., Y.R., P.N.). Cardiology Division, Massachusetts General Hospital (M.C.H., T.G., P.N.). Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (M.C.H., T.G., P.N.). Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA (K.R.C., M.M.U., M.C.H., T.G., P.N.). Search for more papers by this author , Yunfeng RuanYunfeng Ruan https://orcid.org/0000-0002-3213-8309 Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard, Cambridge (K.R.C., M.M.U., M.C.H., T.G., Y.R., P.N.). Search for more papers by this author and Pradeep NatarajanPradeep Natarajan Correspondence to: Pradeep Natarajan, MD, MMSc, Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard, 185 Cambridge St Boston, MA 02114. Email E-mail Address: [email protected] https://orcid.org/0000-0001-8402-7435 Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard, Cambridge (K.R.C., M.M.U., M.C.H., T.G., Y.R., P.N.). Cardiology Division, Massachusetts General Hospital (M.C.H., T.G., P.N.). Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (M.C.H., T.G., P.N.). Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA (K.R.C., M.M.U., M.C.H., T.G., P.N.). Search for more papers by this author Originally published9 Nov 2022https://doi.org/10.1161/CIRCGEN.122.003797Circulation: Genomic and Precision Medicine. 2022;15FootnotesFor Sources of Funding and Disclosures, see page 606 & 607.Correspondence to: Pradeep Natarajan, MD, MMSc, Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard, 185 Cambridge St Boston, MA 02114. Email [email protected]harvard.eduReferences1. Lang IM, Pesavento R, Bonderman D, Yuan JX. Risk factors and basic mechanisms of chronic thromboembolic pulmonary hypertension: a current understanding.Eur Respir J. 2013; 41:462–468. doi: 10.1183/09031936.00049312CrossrefMedlineGoogle Scholar2. Gall H, Hoeper MM, Richter MJ, Cacheris W, Hinzmann B, Mayer E. An epidemiological analysis of the burden of chronic thromboembolic pulmonary hypertension in the USA, Europe and Japan.Eur Respir Rev. 2017; 26:160121. doi: 10.1183/16000617.0121-2016CrossrefMedlineGoogle Scholar3. Dodson MW, Allen-Brady K, Brown LM, Elliott CG, Cannon-Albright LA. Chronic Thromboembolic Pulmonary Hypertension Cases Cluster in Families.Chest. 2019; 155:384–390. doi: 10.1016/j.chest.2018.10.004CrossrefMedlineGoogle Scholar4. Klarin D, Busenkell E, Judy R, Lynch J, Levin M, Haessler J, Aragam K, Chaffin M, Haas M, Lindström S, et al; INVENT Consortium. Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease.Nat Genet. 2019; 51:1574–1579. doi: 10.1038/s41588-019-0519-3CrossrefMedlineGoogle Scholar5. Ge T, Chen CY, Ni Y, Feng YA, Smoller JW. Polygenic prediction via Bayesian regression and continuous shrinkage priors.Nat Commun. 2019; 10:1776. doi: 10.1038/s41467-019-09718-5CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetails December 2022Vol 15, Issue 6 Advertisement Article InformationMetrics © 2022 American Heart Association, Inc.https://doi.org/10.1161/CIRCGEN.122.003797PMID: 36350762 Originally publishedNovember 9, 2022 Keywordsrisk factorspulmonary arteryvenous thromboembolismhypertension, pulmonarygenome-wide association studyPDF download Advertisement SubjectsGenetic, Association Studies