Lanthanide-Assisted Function Tailoring of the HOF-Based Logic Gate Sensor Array for Biothiol Detection and Disease Discrimination

-phenylenediamine (OPD) to generate yellow fluorescent oligomers, accompanied by the fluorescence attenuation of luminol. HOF@Tb functions as a confinement interface that gathers gold nanoclusters (r-AuNCs) with red fluorescence, facilitating an aggregation-induced emission enhancement (AIEE). The fluorescence properties of AuNCs are subsequently impacted to varying degrees by the Au(I)-thiolate motifs from biothiol rooted in an enhanced ligand-metal charge transfer (LMCT) process. Additionally, the catalytic activity of Lumi-HOF@Ce, which exhibits oxidase-like properties, can be inhibited by different biothiols to varying extents. The five-channel fluorescent array demonstrates exceptional discrimination of biothiol fingerprints, aided by machine learning algorithms. Feature-tailored lanthanide HOF sensor arrays achieve sensitive identification with nearly 100% accuracy in classifying clinical liver cancer samples versus normal samples, using a logic gate strategy. The current strategy of lanthanide function tailoring boosts the suitability of biosensing applications.