Experimental research on Cu(II) porphyrin-based metal-organic frameworks used for antimicrobial photodynamic therapy

In recent years, Antimicrobial Photodynamic Therapy (APDT) has been recognized as an attractive antimicrobial treatment option. However, even very effective photosensitizers (PSs) require high photosensitizer concentrations to kill bacteria because of the limited penetration and diffusion of PSS in the bacterial biofilm. In addition, PSs tends to aggregate and to cause self-quenching, which severely limits the therapeutic effect. In the antimicrobial experiment, a porphyrin-based Metal-Organic Framework (MOF) was synthesized, and the prepared materials were characterized by NMR hydrogen spectroscopy, UV-Vis absorption spectroscopy, and FT-IR. The bactericidal performance of the materials was evaluated by antibacterial tests, and the bactericidal effect could reach 100%. It was demonstrated that the Cu (II) porphyrin-based MOF can generate singlet oxygen in the presence of visible light, which provides a promising strategy for antimicrobial therapy.