免疫学
接种疫苗
免疫系统
肺炎球菌疫苗
CD16
流式细胞术
医学
生物
肺炎链球菌
微生物学
CD3型
CD8型
抗生素
作者
Sathyabaarathi Ravichandran,Fernando Erra-Díaz,Emin Onur Karakaslar,Radu Marcheş,Lisa Kenyon-Pesce,Robert J. Rossi,Damien Chaussabel,Djamel Nehar-Belaid,David C. LaFon,Virginia Pascual,Karolina Palucka,Silke Paust,Moon H. Nahm,George A. Kuchel,Jacques Banchereau,Duygu Ucar
标识
DOI:10.1038/s41590-023-01717-5
摘要
Abstract Pneumococcal infections cause serious illness and death among older adults. The capsular polysaccharide vaccine PPSV23 and conjugated alternative PCV13 can prevent these infections; yet, underlying immunological responses and baseline predictors remain unknown. We vaccinated 39 older adults (>60 years) with PPSV23 or PCV13 and observed comparable antibody responses (day 28) and plasmablast transcriptional responses (day 10); however, the baseline predictors were distinct. Analyses of baseline flow cytometry and bulk and single-cell RNA-sequencing data revealed a baseline phenotype specifically associated with weaker PCV13 responses, which was characterized by increased expression of cytotoxicity-associated genes, increased frequencies of CD16 + natural killer cells and interleukin-17-producing helper T cells and a decreased frequency of type 1 helper T cells. Men displayed this phenotype more robustly and mounted weaker PCV13 responses than women. Baseline expression levels of a distinct gene set predicted PPSV23 responses. This pneumococcal precision vaccinology study in older adults uncovered distinct baseline predictors that might transform vaccination strategies and initiate novel interventions.
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