免疫原性
纳米载体
纳米技术
2019年冠状病毒病(COVID-19)
转化式学习
免疫系统
工程伦理学
生化工程
生物技术
医学
生物
药物输送
免疫学
工程类
心理学
材料科学
教育学
疾病
病理
传染病(医学专业)
作者
Amol D. Gholap,Juhi Gupta,Pallavi Kamandar,Deblina D. Bhowmik,Satish Rojekar,Md. Faiyazuddin,Navnath T. Hatvate,Sourav Mohanto,Mohammed Gulzar Ahmed,Vetriselvan Subramaniyan,Vinoth Kumarasamy
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2023-12-14
被引量:1
标识
DOI:10.1021/acsbiomaterials.3c01247
摘要
Nanotechnology has emerged as a transformative pathway in vaccine research and delivery. Nanovaccines, encompassing lipid and nonlipid formulations, exhibit considerable advantages over traditional vaccine techniques, including enhanced antigen stability, heightened immunogenicity, targeted distribution, and the potential for codelivery with adjuvants or immune modulators. This review provides a comprehensive overview of the latest advancements and applications of lipid and non-lipid-based nanovaccines in current vaccination strategies for immunization. The review commences by outlining the fundamental concepts underlying lipid and nonlipid nanovaccine design before delving into the diverse components and production processes employed in their development. Subsequently, a comparative analysis of various nanocarriers is presented, elucidating their distinct physicochemical characteristics and impact on the immune response, along with preclinical and clinical studies. The discussion also highlights how nanotechnology enables the possibility of personalized and combined vaccination techniques, facilitating the creation of tailored nanovaccines to meet the individual patient needs. The ethical aspects concerning the use of nanovaccines, as well as potential safety concerns and public perception, are also addressed. The study underscores the gaps and challenges that must be overcome before adopting nanovaccines in clinical practice. This comprehensive analysis offers vital new insights into lipid and nonlipid nanovaccine status. It emphasizes the significance of continuous research, collaboration among interdisciplinary experts, and regulatory measures to fully unlock the potential of nanotechnology in enhancing immunization and ensuring a healthier, more resilient society.
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