刺
干扰素基因刺激剂
免疫系统
癌症
癌症免疫疗法
免疫学
免疫
获得性免疫系统
免疫检查点
抗原
作者
Huashan Du,Tianmin Xu,Manhua Cui
标识
DOI:10.1016/j.biopha.2020.110972
摘要
Recent studies have shown that the innate immune cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway may play an important role in antitumor immunity. Additionally, the cGAS-STING pathway promotes the senescence of cancer cells, induces apoptosis of cancer cells, and increases the protective effect of cytotoxic T cells and natural killer cell-mediated cytotoxicity. We believe that the combination of the cGAS-STING signaling pathway with other therapeutic methods provides a new perspective from which to overcome obstacles in the application of this review. Further, we highlight the antitumor mechanism of the cGAS-STING signaling pathway and the latest advances in monotherapy and combination therapy with related agonists.
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