代谢工程
生化工程
生产(经济)
生物技术
工程类
生物
生物化学
宏观经济学
经济
酶
作者
Moses Onyeabor,Rodrigo Martı́nez,Gavin Kurgan,Xuan Wang
出处
期刊:Advances in Applied Microbiology
日期:2020-01-01
卷期号:: 33-87
被引量:11
标识
DOI:10.1016/bs.aambs.2020.01.002
摘要
The rapid development in the field of metabolic engineering has enabled complex modifications of metabolic pathways to generate a diverse product portfolio. Manipulating substrate uptake and product export is an important research area in metabolic engineering. Optimization of transport systems has the potential to enhance microbial production of renewable fuels and chemicals. This chapter comprehensively reviews the transport systems critical for microbial production as well as current genetic engineering strategies to improve transport functions and thus production metrics. In addition, this chapter highlights recent advancements in engineering microbial efflux systems to enhance cellular tolerance to industrially relevant chemical stress. Lastly, future directions to address current technological gaps are discussed.
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