小桶
非酒精性脂肪肝
传统医学
丹参
药理学
药方
中医药
药用植物
生物途径
医学
生物信息学
计算生物学
生物
脂肪肝
疾病
基因
生物化学
替代医学
内科学
病理
基因表达
转录组
作者
Jing Ding,Bin Zhang,Pei-Ji Wang,Guo-Nong He,Dong-Mei Wei,Jia-Lu Ding,Bang-Cai Wang
出处
期刊:China journal of Chinese materia medica
[China Journal of Chinese Materia Medica]
日期:2019-04-01
卷期号:44 (8): 1689-1695
被引量:5
标识
DOI:10.19540/j.cnki.cjcmm.20190110.001
摘要
To explore the medication rules of herbal prescriptions for nonalcoholic fatty liver disease,and analyze the possible drug targets and interactions,in order to explore the mechanisms of the herbs. Randomized controlled trials of herbal prescriptions for treating nonalcoholic fatty liver disease were collected from CNKI,Wan Fang,VIP,Sino Med and PubMed databases. The properties,flavors and meridian tropism of herbs were analyzed by using systematic cluster analysis method with SPSS 19. 0 software. Subsequently,the association rules of herbs were analyzed by using Clementine 12. 0 software. Finally,the interactions between targets and relevant signaling pathways were analyzed by Traditional Chinese Medicine Systems Pharmacology Database(TCMSP),Search Tool for the Retrieval of Interacting Genes/Proteins(STRING) and Kyoto Encyclopedia of Genes and Genomes(KEGG). In the 88 prescriptions screened out,the commonly used herbs were Salvia miltiorrhiza,Bupleurum chinense,Alisma orientale,and Crataegus pinnatifida,and the potential signaling pathways were PPAR signaling pathway and calcium signaling pathway. The results showed that the main effects of herbal prescriptions were to improve blood flow/clear blood stasis,clear heatiness/dampness,promote digestion and strengthen spleen. And its mechanism of action may be achieved through the regulation of PPAR signaling pathway and calcium signaling pathway.
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