Methylprednisolone pulse therapy of hematological disorders in systemic lupus erythematosus

Objective To explore methylprednisolone and conventional dose prednisone treatment for hematological damage in systemic lupus erythematosus(SLE) in the near future response. Methods Hemocytopenia in 147 patients with SLE were treated by intravenous injecting methylprednisolone and conventional dose prednisone and therapy response were observed in the tenth day after treatment. Results The responses were obtained in methylprednisolone and in conventional dose prednisone increased percentage of Hb were 34.8% and 14.0%,of WBC were 76.7% and 63.0%,of Pt were 66.7% and 27.3% in two group respectively. In comparison of values of Hb,WBC,and Pt before treatment with those after treatment showed significant difference in two groups(P0.01). Increased values of blood cell in methylprednisolone plus group was significant higher than those of prednisone group, significant difference was existing among tow group(P0.05). Conclusion The short-term efficacy of intravenous injecting methylprednisolone is superior to conventional prednisone. Starting efficacy of the former is earlier and response rate is higher than the latter.