Efficacy and safety of desloratadine in the treatment of chronic idiopathic urticaria: a double-blind, randomized, comparative multicenter trial

Objective: To study the efficacy and safety of desloratadine in chronic idiopathic urticaria(CIU). Methods: This study was a randomized, double-blind, double-analog comparative multicenter trial of 2 weeks'duration. Patients were randomly allocated to receive either desloratadine (n=58) or loratadine one tablet (n=58) once-daily for 14 days, and followed up at 7th day and 14th day after treatment. Results: Of the 116 patients who enrolled the study, 111 cases and 116 cases could be evaluated the efficacy and safety respectively. The total response rates of desloratadine and loratadine were 91.23% and 90.74% , respectively(P0.05). The adverse reactions rates were 20.69% and 16.36%(P0.05). Conclusion: Both desloratadine and loratadine are well tolerated and effective in the treatment of CIU.