To investigate the effects of exercise intervention on breast cancer patients with cancer-related fatigue in different time after chemotherapy,60breast cancer patients who completing the second cycle of chemotherapy and receiving the third cycle of chemotherapy after radical surgery were randomly assigned to control group and study groups,which divided into A,B and C three groups,each group of 15patients.The patients in the study groups received regular nursing care plus aerobic exercise intervention method stipulated by the nurse,respectively on day 1after chemotherapy,day 3after chemotherapy and after chemotherapy were encouraged to take regular exercise,while the patients in control group only received regular nursing care,the revised Piper fatigue scale(RPFS)was used to assess on day 2prior to the chemotherapy,day 1 after chemotherapy(before the exercise intervention)and day 21after chemotherapy.Day 2before the chemotherapy,the score of RPFS of the four groups showed no statistically difference(P0.05),day 21after chemotherapy,patients in the control group had higher score of RPFS than the study groups,the study group C had higher score of RPFS than the study groups of A and B.Exercise as early as possible after chemotherapy can effectively relieve patients with cancer-related fatigue.