Application of liquid chromatography-mass spectrometry in drug related substances analysis

Liquid chromatography-mass spectrometry is regarded as an important technology for many advantages such as high separating efficiency,good sensitivity,and strong specificity.So it is widely used in analysis of drugs and metabolites,chemical medicine mixed illegally in Chinese medicine and drug residues.This paper briefly reviewed its application in drug related substances analysis from Quadrupole Mass Spectrometer,Quadrupole Ion Trap Mass Spectrometer,and Quadrupole-Time of Flight Mass Spectrometer.