A solvent based two component polyurethane paper-plastic lamination adhesive was synthesized, which had lower viscosity and better storage stability in wide containing of polyurethane. The effects of tackifier agent using level,molar ratio of NCO/OH and polyurethane contenting etc on the properties of adhesive were investigated, and the curing process of the adhesive was characterized by IR. The results show that when the molar ratio of NCO/OH is 0.97-0.99 and the mass ratio of prepolymer and the crosslinking agent is 10:(1~1.5),the two-component polyurethane paper-plastic lamination adhesive has best properties and the curing process is completed in 24h at room temperature;initial adhesiveness and peel strength are best when the quality ratio of hydroxyl-containing materials/tackifier is 1/0.45;the coating effect and peel strength are both batter while the containing of polyurethane is in 30%-50% and any of them can be selected according to the case. The final polyurethane lamination adhesive is low-toxic solvent, better bonding property, more bright lamination,no hoar frostand suitability for paper-plastic lamination.