Using the commercial CFD software ANSYS-CFX,numerical simulations of a single stage,high speed centrifugal fan on variable conditions were conducted.The SST turbulence model was employed to obtain the detailed flow field of the centrifugal fan.The axial force calculation of the centrifugal fan with the traditional empirical formula method and the CFD integral method were compared and analyzed.The results show that the change of axial force is greater on variable conditions during operation.The accurate prediction of axial force has important significance for the stable operation of high speed centrifugal fan and the selection of thrust bearing.It can provide reference and guidance for the structural design of high speed centrifugal fan production and the study of axial force prediction.