The relationship between non-alcoholic fatty liver disease and insulin resistance

To study the relationship between non-alcoholic fatty liver disease and insulin resistance.63 non-alcoholic fatty liver disease patients(male 35,femal 28) and 20 obesity without fatty liver disease were selected.Fasting serum insulin levels was measured by radio-immunoassay,insulin resistance index was estimated by the homeostasis model assessment(HOMA-IR).Compared to controlgroup,patients with non-alcoholic fatty liver disease were characterized by hyperinsluinemia,elevated insulin resistance index(P0.01).Serum insulin and insulin resistance index were higher in heavy fatty liver disease patients than medium and light patients(P0.05).In the pathogeneses of non-alcoholic fatty liver disease,insulin resistance was an original factor probably and not a following changing.