化学
抗真菌
抗菌活性
克
席夫碱
立体化学
核化学
细菌
微生物学
生物
遗传学
作者
Khalid Khan,Aqeel Ahmad,Nida Ambreen,Afroze Amyn,Shahnaz Perveen,Shakeel Khan,M. Iqbal Choudhary
标识
DOI:10.2174/1570180810906050363
摘要
3-Formylchromone (1), 3-methyl-7-hydroxychromone (2) and Schiff Bases of 3-formylchromone 3-25 have been synthesized and their antibacterial, antifungal and phytotoxic potentials have been evaluated. Thirteen compounds 1- 7, 14, 17-20 and 22 were screened for their antibacterial effects against fourteen Gram positive and sixteen Gram negative bacterial strains using ampicilline as standard drug. Twelve compounds 1-7, 16-18, 21 and 22 were evaluated against fourteen fungal strains. Eighteen compounds 1-4, 6-13, 15, 17, and 23-25 were screened for their phytotoxic potential and showed varying degree of activity. The structures of the synthesized compounds were determined by using spectroscopic techniques including 1H NMR, EIMS, IR and UV. Elemental analysis results were found to be satisfactory. Keywords: 3-Formylchromone, 3-methyl-7-hydroxychromone, Schiff Bases, Antibacterial, Antifungal, Phytotoxic activity
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