Construction of vein-to-artery interposition graft model in rats

Objective To construct the SD rat model of saphenous vein grafts restenosis after coronary artery bypass grafting. Methods Seventy-five male SD rats were undergone the vein-to-artery interposition,and commonly bred after operation.The specimen were detected at days 1,3,7,14 and 28 after operation,and tissue sections were observed by HE staining. Results Neointimal thickening was greater at the proximal and,to a lesser extent,distal ends,in comparison to the middle of the graft.There was hyperplasia in different degree.Interposition of vein-to-artery showed survival of vein graft endothelial cells.Conclusion The vein-to-artery interposition model is successfully established,and could be an ideal model for further preventing vein graft intimal hyperplasia after bypass grafting.