生物膜
微生物学
变形链球菌
铜绿假单胞菌
细菌
金黄色葡萄球菌
大肠杆菌
化学
抗菌活性
抗菌剂
致病菌
生物
生物化学
遗传学
基因
作者
Yuanna Shen,Pengyu Li,Xiaonan Chen,Yang Zou,Huatian Li,Gang Yuan,Haiyan Hu
出处
期刊:Microbial Drug Resistance
[Mary Ann Liebert]
日期:2020-03-01
卷期号:26 (3): 290-299
被引量:26
标识
DOI:10.1089/mdr.2018.0385
摘要
Bacteria in biofilms are more resistant to antibacterial agents than bacteria in planktonic form. Hence, antibacterial agents should be able to eradicate biofilms to ensure the best outcomes. Little is known about how well many antibacterial agents can disrupt biofilms. In this study, we compared sodium lauryl sulfate (SDS), rhamnolipids (RHL), and N-acetylcysteine (NAC) for their ability to eradicate mature biofilms and inhibit new biofilm formation against Helicobacter pylori, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus mutans. SDS and RHL effectively inhibited formation of five bacterial biofilms in a dose-dependent manner, even at concentrations below the minimal inhibitory concentrations (MICs), suggesting that their antibiofilm activities are unrelated to their antibacterial activities. In contrast, NAC at certain concentrations promoted biofilm formation by all bacteria except P. aeruginosa, whereas at supra-MIC concentrations, it inhibited biofilm formation against the four bacteria, suggesting that its antibiofilm activity depends on its antibacterial activity. NAC was ineffective at eradicating mature H. pylori biofilms, and it actually promoted their formation at concentrations >10 mg/mL. Our results suggest that RHL is superior at eradicating biofilms of H. pylori, E. coli, and S. mutans; SDS is more effective against S. aureus biofilms; and NAC is more effective against P. aeruginosa biofilms. Our results may help determine which antibiofilm agents are effective against certain bacterial strains and develop agents effective against specific bacterial threats.
科研通智能强力驱动
Strongly Powered by AbleSci AI