Wnt信号通路
生物
软骨发生
细胞生物学
神经嵴
软骨内骨化
信号转导
软骨细胞
软骨
间充质干细胞
解剖
胚胎
作者
Stefan Teufel,Christine Hartmann
出处
期刊:Current Topics in Developmental Biology
日期:2019-01-01
卷期号:: 235-279
被引量:48
标识
DOI:10.1016/bs.ctdb.2018.11.010
摘要
As the vertebrate skeleton develops it progresses from a solely cartilaginous scaffold to a mineralized bony skeleton. The cells that build up the skeleton, the chondrocytes and osteoblasts, are primarily of mesodermal origin. Yet, some facial bones, as well as the endocranium, are derived from neural crest cells. The differentiation of the mesenchymal cells to skeletal precursors as well as their subsequent differentiation and maturation along the two lineages, chondrogenic and osteogenic, is controlled by various different signaling pathways, among them Wnt-signaling. WNTs comprise a family of 19 secreted cysteine-rich glycoproteins and can signal through a variety of different intracellular pathways. Genetic loss- and gain-of-function experiments of Wnt-signaling pathway genes have helped to uncover their multiple roles in skeletogenesis, which will be discussed in this article primarily focusing on endochondral bone formation.
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