This cross-sectional analytical research aimed to determine the necessity-concern conceptual framework for predicting medication adherence in older adults with heart failure. The subjects were 107 older adults aged 60-79 years who had been diagnosed with heart failure and received outpatient services in Phrapokklao Hospital, Chanthaburi Province. Systematic random sampling was used to select samples from the samples list. The research instruments were a questionnaire on necessity beliefs and concerns about medication adherence with a reliability was 0.91 and 0.81, respectively, and a medication adherence questionnaire with a reliability was 0.90. The data were collected via telephone from September to December 2022. The data were analyzed by descriptive statistics and multiple logistic regression analysis. The results found that most of the subjects had a high level of medication adherence (86.9%). Both necessity beliefs of medication adherence (AOR = 1.30; 95% CI = 1.01-1.67) and concern beliefs of medication adherence (AOR = 0.76; 95% CI = 0.62-0.92), together, could predict medication adherence of 17.8%. Therefore, nurses or healthcare professionals treating older adults with heart failure should assess beliefs in the necessity and concern of medicine in the low adherence groups and provide the knowledge to patients with inappropriate beliefs to increase medication adherence further.