Therapeutic Potential and Mechanisms of Curcumin in Cardiovascular Diseases: A Comprehensive Review

BACKGROUND: Curcumin is recognized for its therapeutic potential in cardiovascular diseases (CVDs), with effects on cardiomyocytes, vascular function, and hypertrophy. OBJECTIVE: This review aims to evaluate curcumin's therapeutic effects, mechanisms of action, and safety in CVD management. METHODS: A comprehensive review of existing literature was conducted, focusing on curcumin's impact on ischemia, hypoxia, myocardial hypertrophy, fibrosis, and endothelial function. RESULTS: Curcumin protects cardiomyocytes, enhances vascular function, and exhibits inconsistent effects on cholesterol accumulation in macrophages. CONCLUSION: While curcumin shows promise as a complementary agent in CVD management, further research, particularly large-scale clinical trials, is essential to validate its efficacy and safety.