Effect of Antihistamine on the Localization of Trypan Blue in Xylene Treated Areas of Skin

The hyperemia that follows the local application of xylene apparently is not modified by the intravenous and intraperitoneal injections of the antihistamine preparations, Pyrrolazote and Thenylene. Likewise, the localization and concentration of trypan blue in the xylene treated areas of skin are not affected by these preparations of antihistamine. Trypan blue also localizes and concentrates in areas of skin injected intradermally with these preparations of antihistamine.