CD3+ CD8+ CD56− clonal large granular lymphocyte leukaemia and HIV infection

High‐grade malignant lymphomas associated with HIV infection are usually derived from B lymphocytes. Although a broad spectrum of T‐cell‐derived malignancies has been described, no case of monoclonal T large granular lymphocyte leukaemia has been reported to date. We report a case of clonal T‐LGL (CD3 + , CD4 − , CD8 + , CD56 − , CD57 + ) in an HIV‐infected, HTLV1/2‐negative individual. Large granular lymphocytes are thought to represent activated cytotoxic T lymphocytes. HIV infection, as previously reported for HTLV1/2, may represent a pathway of antigen activation and lead to clonal expansion of T large granular lymphocytes.